Deep Phenotyping of the Broader Autism Phenotype in Epilepsy: A Transdiagnostic Marker of Epilepsy and Autism Spectrum Disorder.

Abstract

OBJECTIVE: We conducted deep and minimal phenotyping of the broader autism phenotype (BAP) in people with epilepsy (PWE) and compared its expression with published rates in the general population and relatives of individuals with autism spectrum disorder (ASD-relatives). We then examined the association of clinical epilepsy variables with BAP expression to explore its underpinnings in PWE. METHODS: 103 adults with seizures (M age = 37.37, SD = 12.50; 47% males; 51 temporal lobe epilepsy, 40 genetic generalized epilepsy, 12 other) and 58 community members (M age = 39.59, SD = 14.56; 35% males) underwent deep phenotyping using the observer-rated Autism Endophenotype Interview and minimal pheno..